翻訳と辞書 Words near each other ・ UDP ・ UDP flood attack ・ UDP glucuronosyltransferase 1 family, polypeptide A1 ・ UDP Helper Address ・ UDP hole punching ・ UDP tracker ・ UDP Unicorn ・ UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase ・ UDP-2,3-diacylglucosamine diphosphatase ・ UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase ・ UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase ・ UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase ・ UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase ・ UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase ・ UDP-3-O-acyl-N-acetylglucosamine deacetylase ・ UDP-3-O-N-acetylglucosamine deacetylase ・ UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase ・ UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase ・ UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase ・ UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase ・ UDP-4-amino-4-deoxy-L-arabinose aminotransferase ・ UDP-4-amino-4-deoxy-L-arabinose formyltransferase ・ UDP-arabinopyranose mutase ・ UDP-arabinose 4-epimerase ・ UDP-based Data Transfer Protocol ・ UDP-galactopyranose mutase ・ UDP-galactose—UDP-N-acetylglucosamine galactose phosphotransferase ・ UDP-galacturonate decarboxylase ・ UDP-glucosamine 4-epimerase ・ UDP-glucose 4,6-dehydratase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク UDP-3-O-N-acetylglucosamine deacetylase ： ウィキペディア英語版 UDP-3-O-N-acetylglucosamine deacetylase In molecular biology, UDP-3-O-N-acetylglucosamine deacetylase (also known as UDP-3-O-() N-acetylglucosamine deacetylase or UDP-3-O-acyl-GlcNAc deacetylase), , is a bacterial enzyme involved in lipid A biosynthesis. It is a zinc-dependent metalloamidase that catalyses the second and committed step in the biosynthesis of lipid A. Lipid A anchors lipopolysaccharide (the major constituent of the outer membrane) into the membrane in Gram negative bacteria. It shows no homology to mammalian metalloamidases and is essential for cell viability, making it an important target for the development of novel antibacterial compounds. The structure of UDP-3-O-N-acetylglucosamine deacetylase (LpxC) from ''Aquifex aeolicus'' has a two-layer alpha/beta structure similar to that of the second domain of ribosomal protein S5, only in LpxC there is a duplication giving two structural repeats of this fold, each repeat being elaborated with additional structures forming the active site. LpxC contains a zinc-binding motif, which resides at the base of an active site cleft and adjacent to a hydrophobic tunnel occupied by a fatty acid. This tunnel accounts for the specificity of LpxC toward substrates and inhibitors bearing appropriately positioned 3-O-fatty acid substituents. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「UDP-3-O-N-acetylglucosamine deacetylase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.